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KMID : 0384119900100020423
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Korean Journal of Clinical Pathology
1990 Volume.10 No. 2 p.423 ~ p.436
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A Study on T Cell Subsets of Peripheral Blood in Patients with Gastric Cancer
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J. H. Park
S. H. Kim/S. J. Park/J. K. Seo
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Abstract
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To elucidate alteration of peripheral T cell subsets in gastric cancer patients, the author examined T cell subsets of the peripheral blood in 20 gastric cancer patients as well as 10 age-matched healthy subjects. Diagnoses were confirmed histopathologically in all the patients. All the patients had undergone operation and 12 cases of them were received chemotherapy on the postoperative second week. Blood samples were obtained from veins of the cancer patients before operation and on the postoperative first, second and fourth weeks and those of the control subjects respectively at the Kosin Medical College Hospital during the period from March to August, 1989. Total lymphocyte counts of the peripheral blood were performed on Coulter S-Plus Rr automatic counter. Enumeration of T cell subsets were performed by indirect immunofluorescent method, using monoclonal antibodies, T3, T4 and T8 of Couter clone set. The results obtained were summarized as follows: 1. The percentages and absolute counts of peripheral T3 and T4 cells and T4/T8 ratio were significantly decreased or tended to be decreased in the gastric cancer patients as compared with control subsects. 2. The percentages and absolute counts of peripheral T3 and T4 cells and T4/T8 ratio tended to be decreased as the stage advanced in gastric cancer patients. 3. The percentages of peripheral T3 and T4 cells, and T4/T8 ratio tended to be decreased at the lowest level on the postoperative second week and then returned to he preoperative level on the postoperative fourth week in the stage III, while those tended to be decreased at the lowest level on the second week and it persisted to the postoperative fourth week in the stage lV of the gastric cancer patients. 4. The percentage of T4 cell and T4/T8 ratio tended to be decreased at lowest level on the postoperative second week and it persisted to the postoperative fourth week in the operated gastric cancer patients with chemotherapy, while those tended to be decreased at lowest level on the pastoperative second week and then returned to the preoperative levels on the postoperative fourth week in those without chemotherapy. 5. The absolute counts of T4 and T8 cells tended to be decreased to the lowest level on the postoperative second week and it persisted to the postoperative fourth week in the operated gastric cancer patients with chemotherapy, while those tended to be decreased to the lowest level on postoperative second week and then returned to preoperative levels on the postoperative fourth week in those without chemotherapy. On the basis of this results, it can be suggested that the immunosuppression in gastric cancer patients is due to the decreased helper/inducer T cells and these become more evident as the stage advanced. And it can be suggested that detection of peripheral T cell subsets may be useful to predict the risk of infection and recurrence after operation and chemotherapy in gastric cancer patients.
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